Role of hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia: a report of 2 unique cases

We report, to our knowledge, the first reported case of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) developing 26 years after allogeneic stem cell transplantation for chronic myeloid leukemia (CML). The second case involved de novo Ph+ALL that developed 16 years post-autol...

Full description

Saved in:
Bibliographic Details
Published inBlood cell therapy Vol. 2; no. 3; pp. 36 - 38
Main Authors Lwin, Yadanar, Ma, David
Format Report
LanguageEnglish
Published 01.08.2019
Online AccessGet full text

Cover

More Information
Summary:We report, to our knowledge, the first reported case of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) developing 26 years after allogeneic stem cell transplantation for chronic myeloid leukemia (CML). The second case involved de novo Ph+ALL that developed 16 years post-autologous stem cell transplantation in sustained molecular remission. These cases illustrate and raise some key issues in the management of patients with Ph+ leukemias, including the role of hematopoietic stem cell transplantation, tyrosine kinase inhibitors,and long-term post-transplantation follow-up.
Bibliography:ObjectType-Case Study-2
content type line 59
SourceType-Reports-1
ObjectType-Report-1
ISSN:2432-7026
DOI:10.31547/bct-2019-001