Prozone phenomenon in secondary syphilis with HIV co-infection: Two cases

Prozone phenomenon is defined as a false-negative response resulting from higher antibody titer which interferes with formation of antigen-antibody lattice, necessary to visualize a positive flocculation test. The prozone effect can be observed in syphilis testing with cases of very high antibody ti...

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Bibliographic Details
Published inIndian journal of sexually transmitted diseases and AIDS Vol. 43; no. 2; pp. 183 - 185
Main Authors Awake, Praneet, Angadi, Kalpana, Sen, Sourav, Bhadange, Prasad
Format Report
LanguageEnglish
Published 01.07.2022
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Summary:Prozone phenomenon is defined as a false-negative response resulting from higher antibody titer which interferes with formation of antigen-antibody lattice, necessary to visualize a positive flocculation test. The prozone effect can be observed in syphilis testing with cases of very high antibody titers, such as secondary syphilis, or with human immunodeficiency virus (HIV) co-infection. We report two cases of prozone phenomenon in secondary syphilis with HIV co-infection who initially tested nonreactive for rapid plasma reagin test but tested positive with further higher dilution.
Bibliography:ObjectType-Case Study-2
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SourceType-Reports-1
ObjectType-Report-1
ISSN:2589-0565
DOI:10.4103/ijstd.ijstd_43_22