Integration of metallic endoprostheses in dog femur studied by near-infrared Fourier-transform Raman microscopy
Raman spectra were taken in lateral scans of hydroxyapatite-coated implants in dog femur in step widths of 10-40 microns from the implant surface up to a distance of 320 microns into the bone tissue. The spectra were subjected to a component analysis for the quantitative determination of the protein...
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| Published in | Biomaterials Vol. 23; no. 5; pp. 1337 - 1345 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.03.2002
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| Online Access | Get full text |
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| Summary: | Raman spectra were taken in lateral scans of hydroxyapatite-coated implants in dog femur in step widths of 10-40 microns from the implant surface up to a distance of 320 microns into the bone tissue. The spectra were subjected to a component analysis for the quantitative determination of the protein and the inorganic components. This quantitative analysis is shown to be more reliable than conventional band-fitting procedures and allows the quantitative distinction between the hydroxyapatite form of mature bone tissue and synthetic hydroxyapatite introduced by the implant coating. It is demonstrated that full mineralization of the ongrowing bone is not achieved at 6 months; but, after 18 months, the Raman spectra reveal a complete calcification of the new bone tissue. (Original abstract - amended) |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0142-9612 |