Simultaneous presentation of idiopathic uveitis in monozygotic 4-year-old twin boys

• Published in: American journal of ophthalmology case reports Vol. 27; p. 101666
• Main Authors: Baxter, Sarah, Van Gelder, Russell N, Cheung, Jason C, Basiaga, Matthew L
• Format: Report
• Language: English
• Published: 01.09.2022
• ISSN: 2451-9936
• DOI: 10.1016/j.ajoc.2022.101666

PurposeTo report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis with simultaneous onset. ObservationsHere we report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis. The boys had simultaneous onset of uveitis and identical features. Evaluation, including whole exome sequencing (WES), failed to reveal a specific causative etiology. Each patient responded well to immune modulation and achieved uveitis remission on methotrexate monotherapy off topical glucocorticoids. Conclusions and ImportanceFrom this case of monozygotic twin boys presenting with chronic uveitis, we conclude that monozygotic twins may warrant evaluation in the setting of idiopathic uveitis, especially in young patients unable to express an adequate history.