A case of ischemic stroke accompanied by multiple arterial dissections associated with Klippel-Feil syndrome

• Published in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Vol. 31; no. 5; p. 106399
• Main Authors: Sato, Kazuhiko, Yazawa, Yukako, Igasaki, Shota, Saito, Takuya, Kawabata, Yuichi, Nakashima, Ichiro
• Format: Report
• Language: English
• Published: 01.05.2022
• ISSN: 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2022.106399

OBJECTIVESTo describe the case of an ischemic stroke patient with Klippel-Feil syndrome who developed multiple aneurysms and discuss the mechanism of aneurysm development. MATERIALS AND METHODSA 44-year-old man presented with dizziness, left hemiparesis, and left-sided numbness and was admitted to our department. He developed multiple aneurysms at the bilateral vertebral artery (VA) and bilateral internal carotid artery. RESULTSWe diagnosed the etiology of his brain infarction as an embolic stroke caused by left VA dissection or the large thrombosed aneurysm. Furthermore, we considered that arterial dissection or Hox gene mutation was associated with the development of multiple aneurysms. CONCLUSIONWhile previous reports have described single aneurysm, this is the first report of multiple aneurysms associated with Klippel-Feil syndrome.