Mucin-producing urothelial-type adenocarcinoma of the prostate diagnosed after robot-assisted radical prostatectomy

• Published in: IJU case reports Vol. 5; no. 1; pp. 32 - 35
• Main Authors: Shimizu, Kosuke, Inoue, Ryo, Tomochika, Shinobu, Isoyama, Naohito, Yamamoto, Yoshiaki, Matsumoto, Hiroaki, Shiraishi, Koji, Yoshino, Shigefumi, Tsuzuki, Toyonori, Matsuyama, Hideyasu
• Format: Report
• Language: English
• Published: 01.01.2022
• ISSN: 2577-171X
• DOI: 10.1002/iju5.12380

INTRODUCTIONMucin-producing adenocarcinoma of the prostate is a rare disease that includes prostate adenocarcinoma with mucus production, secondary adenocarcinoma from the bladder or colorectum, and adenocarcinoma from the urothelium of the prostatic urethra. We describe prostate-specific antigen-negative mucin-producing urothelial-type adenocarcinoma of the prostate.CASE PRESENTATIONThe patient had urinary retention and a serum prostate-specific antigen level of 0.74 ng/mL. Computed tomography and magnetic resonance imaging revealed a prostate tumor with a mucous component. We diagnosed adenocarcinoma by prostate biopsy and subsequently performed robot-assisted radical prostatectomy. Mucin-producing urothelial-type adenocarcinoma of the prostate was diagnosed by pathological examinations. Lung metastasis, developing within 3 months after surgery, was treated using chemotherapy.CONCLUSIONEndocrine therapy is ineffective for mucin-producing urothelial-type adenocarcinoma of the prostate. Mucin-producing urothelial-type adenocarcinoma of the prostate diagnosis requires pathological and immunohistochemical analyses. It is important to surgically remove the primary lesion, and robot-assisted radical prostatectomy may provide an effective approach. Multimodal therapy is essential to treat for mucin-producing urothelial-type adenocarcinoma of the prostate.