The input of GATA-3 in the identification of parathyroid carcinoma diagnosis: Case report with review of literature

INTRODUCTIONand Importance: Parathyroid carcinoma is an exceptional cancer, with significant morbidity and mortality, associated with parathyroid hormone (PTH) mediated hypercalcemia. CASE PRESENTATIONWe report a case of parathyroid carcinoma with a difficult histological diagnosis. This case illust...

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Published inAnnals of medicine and surgery (2012) Vol. 68; p. 102571
Main Authors Lajmi, Zainab, Bdioui, Ahlem, Bchir, Ahlem, Ben Ammou, Emene, Missaoui, Nabiha, Hmissa, Sihem
Format Report
LanguageEnglish
Published 01.08.2021
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Summary:INTRODUCTIONand Importance: Parathyroid carcinoma is an exceptional cancer, with significant morbidity and mortality, associated with parathyroid hormone (PTH) mediated hypercalcemia. CASE PRESENTATIONWe report a case of parathyroid carcinoma with a difficult histological diagnosis. This case illustrates the usefulness of the immunohistochemical marker "GATA-3" in parathyroid differentiation especially in tumours. CLINICAL DISCUSSIONThe diagnosis of parathyroid carcinoma is challenging without the knowledge of the clinical information, laboratory finding, and radiographic imaging studies. The immunohistochemistry is useful tool in these cases to identify the parathyroid origin of neoplasia. GATA-3 is a transcription factor that is involved in the embryonic development of the parathyroid glands and in adult parathyroid cell proliferation. CONCLUSIONIt is concluded that GATA-3 is a very sensitive and relatively specific immunohistochemical marker for parathyroid differentiation that can assist in the differential diagnosis of parathyroid tumours.
Bibliography:ObjectType-Case Study-2
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ISSN:2049-0801
2049-0801
DOI:10.1016/j.amsu.2021.102571