Method and Apparatus for a Miniature Bioreactor System for Long-Term Cell Culture

A bioreactor and method that permits continuous and simultaneous short, moderate, or long term cell culturing of one or more cell types or tissue in a laminar flow configuration is disclosed, where the bioreactor supports at least two laminar flow zones, which are isolated by laminar flow without th...

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Bibliographic Details
Published inNASA Center for AeroSpace Information (CASI). Misc. Resources
Main Authors Kleis, Stanley J, Geffert, Sandra K, Gonda, Steve R
Format Web Resource
LanguageEnglish
Published Hampton NASA/Langley Research Center 05.05.2015
Subjects
Bioreactors
Biotechnology
Cell culture
Hypoxia
Laminar flow
Long term
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Summary:A bioreactor and method that permits continuous and simultaneous short, moderate, or long term cell culturing of one or more cell types or tissue in a laminar flow configuration is disclosed, where the bioreactor supports at least two laminar flow zones, which are isolated by laminar flow without the need for physical barriers between the zones. The bioreactors of this invention are ideally suited for studying short, moderate and long term studies of cell cultures and the response of cell cultures to one or more stressors such as pharmaceuticals, hypoxia, pathogens, or any other stressor. The bioreactors of this invention are also ideally suited for short, moderate or long term cell culturing with periodic cell harvesting and/or medium processing for secreted cellular components.
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