First Detection of Plasmid-Encoded blaOXY ?-Lactamase

Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY ?-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that...

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Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 53; no. 7; pp. 3143 - 3146
Main Authors Gonzalez-Lopez, J J, Coelho, A, Larrosa, M N, Lavilla, S, Bartolome, R, Prats, G
Format Journal Article
LanguageEnglish
Published 01.07.2009
Subjects
Klebsiella oxytoca
Klebsiella pneumoniae
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Summary:Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY ?-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored blaOXY-1, which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the blaOXY-1-carrying plasmid. This is the first report of a plasmid-encoded OXY ?-lactamase.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01473-08