CASE REPORT: Postinfantile giant-cell hepatitis associated with ulcerative colitis and autoimmune hepatitis

Postinfantile giant cell hepatitis (PGCH) is rare. It is characterized by the presence of multinucleated giant cells in liver biopsy, and although it has been associated with several etiological agents, in many cases its etiology remains unclear. The case is presented herein of an adult woman with P...

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Published inJournal of gastroenterology and hepatology Vol. 21; no. 12; pp. 1863 - 1864
Main Authors Anagnostopoulos, George K, Margantinis, George, Tsiakos, Stavros, Kostopoulos, Panagiotis, Grigoriadis, Kyriakos, Arvanitidis, Dimitrios
Format Journal Article
LanguageEnglish
Published 01.12.2006
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Summary:Postinfantile giant cell hepatitis (PGCH) is rare. It is characterized by the presence of multinucleated giant cells in liver biopsy, and although it has been associated with several etiological agents, in many cases its etiology remains unclear. The case is presented herein of an adult woman with PGCH in the setting of ulcerative colitis and autoimmune hepatitis. The presence of autoimmune hepatitis in the patient is consistent and supports the autoimmune pathogenesis of PGCH in a subgroup of patients. Furthermore, this finding, along with others, suggests that PGCH may be included in the list of hepatic complications of inflammatory bowel disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2006.03271.x