TNF-a and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-a and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical d...

Full description

Saved in:
Bibliographic Details
Published inJournal of neuroimmunology Vol. 216; no. 1-2; pp. 92 - 97
Main Authors Kamer, A R, Craig, R G, Pirraglia, E, Dasanayake, AP, Norman, R G, Boylan, R J, Nehorayoff, A, Glodzik, L, Brys, M, de Leon, MJ
Format Journal Article
LanguageEnglish
Published 30.11.2009
Online AccessGet full text

Cover

More Information
Summary:The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-a and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-a and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-a classification of clinical AD and NL. This study shows that TNF-a and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0165-5728
DOI:10.1016/j.jneuroim.2009.08.013