Regulation of FcRI Expression on Monocytic Cell Lines

• Published in: International archives of allergy and immunology Vol. 118; no. 2-4; pp. 294 - 295
• Main Authors: Dubois, G R, Reischl, I G, Peiritsch, S, Brown, K, Wheat, L, Effenberger, F, Woisetschlaeger, M, Mudde, G C
• Format: Journal Article
• Language: English
• Published: 01.02.1999
• ISSN: 1018-2438; 1423-0097
• DOI: 10.1159/000024105

Sorry, there is no abstract. Read the first few lines of the text instead! The high affinity receptor for IgE, FcRI, as one of the key structures involved in allergic inflammation [reviewed in 1] has become a focus of immunological research. Human FcRI expression, initially thought to be limited to mast cells and basophils as an alpha beta gamma gamma FcRI complex, has now clearly been demonstrated on Langerhans' cells, dendritic cells and monocytes [reviewed in 2]. On these cells, however, the lack of beta -chain protein from the FcRI complex is held responsible for structural and functional differences [2, 3]. The recent establishment of FcRI-expressing human monocytic cell lines [4, 5] allows for the confirmation of experiment results, obtained in the 'classical' FcRI model, the rat basophilic leukemia cell.