Preparation, quality control and stability of super(99m)Tc-cefuroxime axetil

Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with super(99m)Tc. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated...

Full description

Saved in:
Bibliographic Details
Published inJournal of radioanalytical and nuclear chemistry Vol. 275; no. 1; pp. 161 - 164
Main Authors Yurt Lambrecht, F, Durkan, K, Unak, P
Format Journal Article
LanguageEnglish
Published 01.01.2008
Online AccessGet full text

Cover

More Information
Summary:Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with super(99m)Tc. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated. The radiochemical purity of super(99m)Tc-cefuroxime axetil was determined by thin layer radio chromatography (TLRC), electrophoresis and high performance liquid chromatography. The maximum radiolabeling yield was 98 plus or minus 1%.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-2
ISSN:0236-5731
DOI:10.1007/s10967-007-6999-0