CASE REPORT: Aspergillus brain abscess in a patient with acute myeloid leukaemia successfully treated with voriconazole

Cerebral aspergillosis is associated with very high mortality in immunocompromised hosts. Conventional antifungal agents like amphotericin-B and itraconazole are almost ineffective in cerebral aspergillosis. Newer azoles have been shown to penetrate the blood, cerebrospinal fluid barrier and achieve...

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Published inClinical and laboratory haematology Vol. 28; no. 2; pp. 130 - 133
Main Authors Wandroo, F, Stableforth, P, Hasan, Y
Format Journal Article
LanguageEnglish
Published 01.04.2006
Subjects
Aspergillus
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Summary:Cerebral aspergillosis is associated with very high mortality in immunocompromised hosts. Conventional antifungal agents like amphotericin-B and itraconazole are almost ineffective in cerebral aspergillosis. Newer azoles have been shown to penetrate the blood, cerebrospinal fluid barrier and achieve effective fungicidal concentrations. These newer azoles may change the outlook of this fatal condition. We report here a patient with cerebral aspergillosis who was successfully treated with voriconazole.
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ISSN:0141-9854
1365-2257
DOI:10.1111/j.1365-2257.2006.00737.x