Fast Water-Exchange Gd super(3+)-(DO3A-like) Complex Functionalized with Aza-15-Crown-5 Showing Prolonged Residence Lifetime in Vivo

A bis-hydrated Gd super(3+) complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k sub(ex) = 3.1 x 10 super(7) s super(-1)) and low acute cytotoxicity. Efficient magnetic resonance sig...

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Published inBioconjugate chemistry Vol. 17; no. 3; pp. 571 - 574
Main Authors Li, C, Li, Y-X, Law, G-L, Man, K, Wong, W-T, Lei, H
Format Journal Article
LanguageEnglish
Published 01.05.2006
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Summary:A bis-hydrated Gd super(3+) complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k sub(ex) = 3.1 x 10 super(7) s super(-1)) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.
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ISSN:1043-1802
DOI:10.1021/bc060003m