Granulocyte colony stimulating factor in HCV genotype-1 patients who develop Peg-IFN-a2b related severe neutropenia: A preliminary report on treatment, safety and efficacy

• Published in: Journal of medical virology Vol. 81; no. 5; pp. 848 - 852
• Main Authors: Koskinas, John, Zacharakis, George, Sidiropoulos, John, Elefsiniotis, John, Savvas, Savvas, Kotsiou, Stamatia, Kountouras, Dimitrios, Schina, Maria, Kostopoulos, Panagiotis, Archimandritis, Athanasios
• Format: Journal Article
• Language: English
• Published: 01.05.2009
• Subjects: Hepatitis C virus
• ISSN: 0146-6615
• DOI: 10.1002/jmv.21467

Dose reductions of Peg-IFNa because of severe neutropenia may affect the virologic response in patients with hepatitis C infection (HCV). Granulocyte colony-stimulating factor (G-CSF) has been used occasionally but studies addressing its safety and efficacy in the current treatment of HCV infection are missing. The database of 232 naive patients with HCV genotype-1 who received PEG-IFN2b 1.5 mcg/kg/week plus Ribavirin 800-1,400 mg/day and completed the treatment was examined. Nineteen patients who exhibited significant neutropenia and received 150-300 µg G-CSF (Group A) with 19 matched control patients who had dose reductions of Peg-IFN according to the standard recommendations (Group B) were examined. None of the patients had treatment modifications due to thrombocytopenia or anemia. The mean decline of the neutrophils was similar in groups A and B (1,760 ± 1,030/mm3 at 11 ± 8.6 weeks and 1,630 ± 890 at 12.3 ± 6.1, respectively). Nadir neutrophil values were also not statistically different. Patients who received G-CSF two before IFN, maintained neutrophils between 1,400/mm3 and 2,700/mm3 and remained on G-CSF for 29 weeks (2-40). Virologic response at the end of treatment was observed in 12/19 (63%) patients and at 6 months follow-up in 6/19 (32%) in group A as compared to 9/19 (47%) and 4/19 (21%) in group B, respectively. No side effects related to G-CSF were encountered. Administration of G-CSF 2 days before Peg-IFN is safe, maintains sustained neutrophil count, improves adherence to treatment and seems to increase the virologic response in patients infected with HCV genotype 1 who develop Peg-IFN-2b related severe neutropenia. J. Med. Virol. 81:848-852, 2009.