N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamid es as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamid es targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized. The potency of these inhibitors was influenced by the nature of the heteroaryl fragment with the thiophene anal...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 19; no. 4; pp. 1218 - 1223
Main Authors Allan, Martin, Manku, Sukhdev, Therrien, Eric, Nguyen, Natalie, Styhler, Sylvia, Robert, Marie-France, Goulet, Anne-Christine, Petschner, Andrea J, Rahil, Gabi, MacLeod, A Robert, Deziel, Robert, Besterman, Jeffrey M, Nguyen, Hannah, Wahhab, Amal
Format Journal Article
LanguageEnglish
Published 01.02.2009
Online AccessGet full text

Cover

More Information
Summary:A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamid es targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized. The potency of these inhibitors was influenced by the nature of the heteroaryl fragment with the thiophene analogues being superior to thiazole, pyridine, isoindoline and benzofuran based inhibitors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-2
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2008.12.075