Influence of a single oral dose of vitamin D sub(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients

• Published in: The international journal of tuberculosis and lung disease Vol. 13; no. 1; pp. 119 - 125
• Main Authors: Martineau, A R, Nanzer, A M, Satkunam, K R, Packe, GE, Rainbow, S J, Maunsell, Z J, Timms, P M, Venton, T R, Eldridge, S M, Davidson, R N, Wilkinson, R J, Griffiths, C J
• Format: Journal Article
• Language: English
• Published: 01.01.2009
• Subjects: Mycobacterium
• ISSN: 1027-3719

SETTING: Newham Chest Clinic, London, UK. OBJECTIVE: To determine the safety and efficacy of the administration of bolus-dose vitamin D sub(2) in elevating serum 25-hydroxyvitamin D (25[OH]D) concentrations in tuberculosis (TB) patients. DESIGN: A multi-ethnic cohort of TB patients was randomised to receive a single oral dose of 2.5 mg vitamin D sub(2) (n = 11) or placebo (n = 14). Serum 25(OH)D and corrected calcium concentrations were determined at baseline and 1 week and 8 weeks post-dose, and compared to those of a multi-ethnic cohort of 56 healthy adults receiving an identical dose of vitamin D sub(2). RESULTS: Hypovitaminosis D (serum 25[OH]D < 75 nmol/1) was present in all patients at baseline. A single oral dose of 2.5 mg vitamin D sub(2) corrected hypovitaminosis D in all patients in the intervention arm of the study at 1 week post-dose, and induced a 109.5 nmol/1 mean increase in their serum 25(OH)D concentration. Hypovitaminosis D recurred in 10/11 patients at 8 weeks post-dose. No patient receiving vitamin D sub(2) experienced hypercalcacmia. Patients receiving 2.5 mg vitamin D sub(2)experienced a greater mean increase in serum 25(OH)D at 1 week post-dose than healthy adults receiving 2.5 mg vitamin D sub(2). CONCLUSION: A single oral dose of 2.5 mg vitamin D sub(2)corrects hypovitaminosis D at 1 week but not at 8 weeks post-dose in TB patients.