Case report: Continuous venovenous hemodiafiltration to treat controlled-release carbamazepine overdose in a pediatric patient

Carbamazepine (CBZ) intoxication is an important issue in acute poisoning practice. Highly protein-bound, CBZ is not removed efficiently through conventional hemodialysis. We describe the use of continuous venovenous hemodiafiltration (CVVHDF) in a 2-year-old boy who developed general tonic clonic s...

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Published inPediatric anesthesia Vol. 16; no. 11; pp. 1176 - 1178
Main Authors Yildiz, Tulay Sahin, Toprak, Demet Gedikbasi, Arisoy, Emin Sami, Solak, Mine, MD, Kamil Toker
Format Journal Article
LanguageEnglish
Published 01.11.2006
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Summary:Carbamazepine (CBZ) intoxication is an important issue in acute poisoning practice. Highly protein-bound, CBZ is not removed efficiently through conventional hemodialysis. We describe the use of continuous venovenous hemodiafiltration (CVVHDF) in a 2-year-old boy who developed general tonic clonic seizure and respiratory depression due to controlled-release formula of CBZ overdose (peak drug level of >20 mu g.ml super(-1), therapeutic range: 5-10 mu g.ml super(-1)). Serum CBZ concentrations fell to 0.25 mu g.ml super(-1) at the end of hemodiafiltration. The patient recovered rapidly and was discharged from hospital 4 days from the time of ingestion with no complications or neurologic impairment.
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ISSN:1155-5645
1460-9592
DOI:10.1111/j.1460-9592.2006.01955.x