Applications of supercritical CO sub(2) in the fabrication of polymer systems for drug delivery and tissue engineering

• Published in: Advanced drug delivery reviews Vol. 60; no. 3; pp. 373 - 387
• Main Authors: Davies, Owen R, Lewis, Andrew L, Whitaker, Martin J, Tai, Hongyun, Shakesheff, Kevin M, Howdle, Steven M
• Format: Journal Article
• Language: English
• Published: 01.02.2008
• ISSN: 0169-409X
• DOI: 10.1016/j.addr.2006.12.001

Supercritical CO sub(2) has the potential to be an excellent environment within which controlled release polymers and dry composites may be formed. The low temperature and dry conditions within the fluid offer obvious advantages in the processing of water, solvent or heat labile molecules. The low viscosity and high diffusivity of scCO sub(2) offer the possibility of novel processing routes for polymer drug composites, but there are still technical challenges to overcome. Moreover, the low solubility of most drug molecules in scCO sub(2) presents both challenges and advantages. This review explores the current methods that use high pressure and scCO sub(2) for the production of drug delivery systems and the more specialized application of the fluid in the formation of highly porous tissue engineering scaffolds.