Synthesis and properties of a symmetric dimeric bisbenzimidazole, a DNA-specific ligand

Dimeric bisbenzimidazole DB(5) fluorescing in the blue spectral area ( lambda sub(em) 476 nm) within the DNA complex was synthesized. DB(5) is bound by a double-strand DNA and can differentially stain human and plant (flax) chromosomes. According to preliminary data, it provides a considerably more...

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Published inRussian journal of bioorganic chemistry Vol. 34; no. 2; pp. 261 - 263
Main Authors Ivanov, A A, Streltsov, SA, Prikazchikova, T A, Gottikh, M B, Zhuze, AL
Format Journal Article
LanguageEnglish
Published 01.03.2008
Subjects
Human immunodeficiency virus 1
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Summary:Dimeric bisbenzimidazole DB(5) fluorescing in the blue spectral area ( lambda sub(em) 476 nm) within the DNA complex was synthesized. DB(5) is bound by a double-strand DNA and can differentially stain human and plant (flax) chromosomes. According to preliminary data, it provides a considerably more intensive contrast of chromosome staining than DAPI and Hoechst 33258 dyes. It was also found that DB(5) is an in vitro inhibitor of HIV-1 integrase in the reaction of 3'-processing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1068-1620
1608-330X
DOI:10.1007/s11171-008-2018-7