Design and synthesis of oxime ethers of ^a-acyl-^b-phenylpropanoic acids as PPAR dual agonists

Oxime ethers of ^a-acyl-^b-phenylpropanoic acids were prepared to apply as PPAR^a and ^g dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC@@d50@ of 19 and 13 nM in PPAR^a and ^g, respectively. It showed better glucose lowering effects than rosiglitazone 1 a...

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Published inBioorganic & medicinal chemistry letters Vol. 17; no. 4; pp. 937 - 941
Main Authors Han, Hee Oon, Kim, Seung Hae, Kim, Kyoung-Hee, Hur, Gwong-Cheung, Yim, Hyeon Joo, Chung, Hee-Kyung, Woo, Sung Ho, Koo, Ki Dong, Lee, Chang-Seok, Koh, Jong Sung, Kim, Geun Tae
Format Journal Article
LanguageEnglish
Published 01.02.2007
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Summary:Oxime ethers of ^a-acyl-^b-phenylpropanoic acids were prepared to apply as PPAR^a and ^g dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC@@d50@ of 19 and 13 nM in PPAR^a and ^g, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in @@idb@/@@idb@ mice model.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.11.050