1,5-Benzodioxepin derivatives as a novel class of muscarinic M@@d3@ receptor antagonists

The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M@@d1@-M@@d3@ receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M@@d3@ receptor and potent effect on rhythmic increase in bladder pressure...

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Published inBioorganic & medicinal chemistry letters Vol. 17; no. 4; pp. 925 - 931
Main Authors Sonda, Shuji, Katayama, Kenichi, Fujio, Masakazu, Sakashita, Hiroshi, Inaba, Kenichi, Asano, Kiyoshi, Akira, Toshiaki
Format Journal Article
LanguageEnglish
Published 01.02.2007
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Abstract The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M@@d1@-M@@d3@ receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M@@d3@ receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.
AbstractList The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M@@d1@-M@@d3@ receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M@@d3@ receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.
Author Inaba, Kenichi
Sonda, Shuji
Asano, Kiyoshi
Fujio, Masakazu
Sakashita, Hiroshi
Katayama, Kenichi
Akira, Toshiaki
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