1,5-Benzodioxepin derivatives as a novel class of muscarinic M@@d3@ receptor antagonists

The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M@@d1@-M@@d3@ receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M@@d3@ receptor and potent effect on rhythmic increase in bladder pressure...

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Published inBioorganic & medicinal chemistry letters Vol. 17; no. 4; pp. 925 - 931
Main Authors Sonda, Shuji, Katayama, Kenichi, Fujio, Masakazu, Sakashita, Hiroshi, Inaba, Kenichi, Asano, Kiyoshi, Akira, Toshiaki
Format Journal Article
LanguageEnglish
Published 01.02.2007
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Summary:The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M@@d1@-M@@d3@ receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M@@d3@ receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-1
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.11.058