Cl super(-) conduction of GABA sub(A) receptor complex on synaptic membranes in rat cortex at the early stage of chronic cerebral epileptization

Experiments on Wistar rats showed that muscimol-stimulated Cl super(-) conduction of synaptoneurosomes, isolated from the cerebral cortex increased after 5-day systemic treatment with subconvulsive doses of pentylene tetrasole during the initial stage of pharmacological pentylene tetrasole kindling,...

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Published inBulletin of experimental biology and medicine Vol. 142; no. 2; pp. 176 - 178
Main Authors Rebrov, I G, Karpova, M N, Andreev, A A, Klishina, NYu, Kalinina, M V, Kuzina, O S, Kuznetsova, LV
Format Journal Article
LanguageEnglish
Published 01.08.2006
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Summary:Experiments on Wistar rats showed that muscimol-stimulated Cl super(-) conduction of synaptoneurosomes, isolated from the cerebral cortex increased after 5-day systemic treatment with subconvulsive doses of pentylene tetrasole during the initial stage of pharmacological pentylene tetrasole kindling, characterized by gradually augmenting convulsive readiness of the brain. This indicates an increase in functional activity of the GABA sub(A) receptor/Cl super(-) ionophore complex.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0320-z