Potent bradykinin B sub(1) receptor antagonists: 4-Substituted phenyl cyclohexanes

• Published in: Bioorganic & medicinal chemistry letters Vol. 17; no. 11; pp. 3006 - 3009
• Main Authors: Su, Dai-Shi, Lim, John L, Markowitz, MKristine, Wan, Bang-Lin, Murphy, Kathy L, Reiss, Duane R, Harrell, CMeacham, O'Malley, Stacy S, Ransom, Rick W, Chang, Raymond SL, Pettibone, Douglas J, Tang, Cuyue, Prueksaritanont, Thomayant, Freidinger, Roger M, Bock, Mark G
• Format: Journal Article
• Language: English
• Published: 01.06.2007

Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided...