Potent bradykinin B sub(1) receptor antagonists: 4-Substituted phenyl cyclohexanes

Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 17; no. 11; pp. 3006 - 3009
Main Authors Su, Dai-Shi, Lim, John L, Markowitz, MKristine, Wan, Bang-Lin, Murphy, Kathy L, Reiss, Duane R, Harrell, CMeacham, O'Malley, Stacy S, Ransom, Rick W, Chang, Raymond SL, Pettibone, Douglas J, Tang, Cuyue, Prueksaritanont, Thomayant, Freidinger, Roger M, Bock, Mark G
Format Journal Article
LanguageEnglish
Published 01.06.2007
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Summary:Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B sub(1) receptor antagonists.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Feature-2
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.03.059