Potent bradykinin B sub(1) receptor antagonists: 4-Substituted phenyl cyclohexanes
Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided...
Saved in:
| Published in | Bioorganic & medicinal chemistry letters Vol. 17; no. 11; pp. 3006 - 3009 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.06.2007
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B sub(1) receptor antagonists. |
|---|---|
| AbstractList | Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B sub(1) receptor antagonists. |
| Author | Freidinger, Roger M Markowitz, MKristine Ransom, Rick W Harrell, CMeacham Lim, John L Chang, Raymond SL O'Malley, Stacy S Tang, Cuyue Murphy, Kathy L Prueksaritanont, Thomayant Su, Dai-Shi Pettibone, Douglas J Reiss, Duane R Wan, Bang-Lin Bock, Mark G |
| Author_xml | – sequence: 1 givenname: Dai-Shi surname: Su fullname: Su, Dai-Shi – sequence: 2 givenname: John surname: Lim middlename: L fullname: Lim, John L – sequence: 3 givenname: MKristine surname: Markowitz fullname: Markowitz, MKristine – sequence: 4 givenname: Bang-Lin surname: Wan fullname: Wan, Bang-Lin – sequence: 5 givenname: Kathy surname: Murphy middlename: L fullname: Murphy, Kathy L – sequence: 6 givenname: Duane surname: Reiss middlename: R fullname: Reiss, Duane R – sequence: 7 givenname: CMeacham surname: Harrell fullname: Harrell, CMeacham – sequence: 8 givenname: Stacy surname: O'Malley middlename: S fullname: O'Malley, Stacy S – sequence: 9 givenname: Rick surname: Ransom middlename: W fullname: Ransom, Rick W – sequence: 10 givenname: Raymond surname: Chang middlename: SL fullname: Chang, Raymond SL – sequence: 11 givenname: Douglas surname: Pettibone middlename: J fullname: Pettibone, Douglas J – sequence: 12 givenname: Cuyue surname: Tang fullname: Tang, Cuyue – sequence: 13 givenname: Thomayant surname: Prueksaritanont fullname: Prueksaritanont, Thomayant – sequence: 14 givenname: Roger surname: Freidinger middlename: M fullname: Freidinger, Roger M – sequence: 15 givenname: Mark surname: Bock middlename: G fullname: Bock, Mark G |
| BookMark | eNqNyrFOwzAQAFALFYm08ANMnhAMMefGDoQRVMSICgNb5bgHdXHtkDtL5O9h4AOY3vLmYpZyQiHONSgNur3eq_7go1oC3ChoFNjuSFTatKZuDNiZqKBrob7tzNuJmBPtAbQBYyqxfs6MiWU_uu30GVJI8l5S6S_1lRzR48B5lC6x-8gpENOdNPVL6YkDF8atHHaYpij95GPe4bdLSKfi-N1FwrM_F-LicfX68FQPY_4qSLw5BPIY42_OhTa6s9ouG9v8O_4AFF9MRg |
| ContentType | Journal Article |
| DBID | 7QO 8FD FR3 P64 |
| DOI | 10.1016/j.bmcl.2007.03.059 |
| DatabaseName | Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitle | Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitleList | Biotechnology Research Abstracts |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Anatomy & Physiology |
| EISSN | 1464-3405 |
| EndPage | 3009 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5VS 6TJ 7-5 71M 7QO 8FD 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXKI AAXUO ABBQC ABFNM ABGSF ABJNI ABMAC ABUDA ABXDB ABZDS ACDAQ ACGFS ACIUM ACNNM ACRLP ADBBV ADECG ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJRQY AJSZI AKRWK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 D0L EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FR3 FYGXN G-Q HZ~ IHE J1W KOM LZ2 M29 M2Z M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-9 P2P P64 PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPC SPCBC SSH SSK SSP SSU SSZ T5K YK3 ZMT ~02 ~G- |
| ID | FETCH-proquest_miscellaneous_195152353 |
| ISSN | 0960-894X |
| IngestDate | Fri Oct 25 09:28:22 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-proquest_miscellaneous_195152353 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
| PQID | 19515235 |
| PQPubID | 23462 |
| ParticipantIDs | proquest_miscellaneous_19515235 |
| PublicationCentury | 2000 |
| PublicationDate | 20070601 |
| PublicationDateYYYYMMDD | 2007-06-01 |
| PublicationDate_xml | – month: 06 year: 2007 text: 20070601 day: 01 |
| PublicationDecade | 2000 |
| PublicationTitle | Bioorganic & medicinal chemistry letters |
| PublicationYear | 2007 |
| SSID | ssj0014044 |
| Score | 3.7184916 |
| Snippet | Selective bradykinin (BK) B sub(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the... |
| SourceID | proquest |
| SourceType | Aggregation Database |
| StartPage | 3006 |
| Title | Potent bradykinin B sub(1) receptor antagonists: 4-Substituted phenyl cyclohexanes |
| URI | https://search.proquest.com/docview/19515235 |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEF6qgnoRbRXf7kFECRuS5tV4a0tFpFXRir2VZLNqtSaiKVIFf7uzu0maasHHJaRJSQLz8e3szDczCO3aAYU7lk08Q4cNiu25xPWcG6JZlPqwZPlUiDFbp_bxlXnSsTqFwnu-uiT2Vfo2sa7kP1aFa2BXXiX7B8tmD4ULcA72hSNYGI6_svF5FPNUPmx4g-EDn_Sg1JSXgc97L_HdPpAZe4qFSpLnnniPXCGAMwmnC6kRCBQu8hr2FTqk_eiOV7skqsI009uL5OQnKlCS5OJ5V5F0VJzSFyVBmXN-OZBi-R65vOtlgh85tVkIdbJ4My8Uil57YqSs0pJ8M0rzX8vYbM0Lb0kzaRCexieckY4qDTTaGqm4UoepMkmzpm0Sw9SsMR528njTc6xqaJqdW6HhpzuR_WUg4l71H2k_6U5pqFrScXys1fbpWffoqtnsthud9hSaKQNLcXpUPzJ9EG87JHqPpZ-fVFxJceDXN3xbyYV70l5EC8m-AlclSJZQgYVFVKqGXhw9DvEeFkpfkUIporl6aroimm0l4ooSupBwwiM44RoGOO3rBziFEs5B6RCPAQlLIOE8kJbR3lGjXT8m6Wd34b08VwQ3o8FLVwfP2yoblrGCpsMoZKsIlx3PscF9NlyTmrrJKowBA5SdAJwfFmjGGtr54WHrP_5jA82PMLSJpuPnAdsCry_2t4V1PgE_fF7x |
| link.rule.ids | 315,783,787,27936,27937 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Potent+bradykinin+B+sub%281%29+receptor+antagonists%3A+4-Substituted+phenyl+cyclohexanes&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.au=Su%2C+Dai-Shi&rft.au=Lim%2C+John+L&rft.au=Markowitz%2C+MKristine&rft.au=Wan%2C+Bang-Lin&rft.date=2007-06-01&rft.issn=0960-894X&rft.eissn=1464-3405&rft.volume=17&rft.issue=11&rft.spage=3006&rft.epage=3009&rft_id=info:doi/10.1016%2Fj.bmcl.2007.03.059&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0960-894X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0960-894X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0960-894X&client=summon |