NKG2C super(+) NK Cells Are Enriched in AIDS Patients with Advanced-Stage Kaposi's Sarcoma

Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C super(+) NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients accordin...

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Published inJournal of virology Vol. 81; no. 1; pp. 430 - 433
Main Authors Goodier, Martin R, Mela, C M, Steel, A, Gazzard, B, Bower, M, Gotch, F
Format Journal Article
LanguageEnglish
Published 01.01.2007
Subjects
Human immunodeficiency virus 1
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Summary:Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C super(+) NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients according to the AIDS Clinical Trial Group criteria revealed that patients with the S1 disease stage have a significantly higher proportion of NKG2C super(+) cells than those with the S0 disease stage. NKG2C super(+) cells from S1-stage patients are highly enriched for the expression of KIR3DL1, are depleted of NKp46, and respond poorly to major histocompatibility complex class I-positive target cells. These data demonstrate a link between NK cell phenotype and function and disease prognosis in AIDS.
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ISSN:0022-538X
1098-5514