Cameo: Angiolymphoid hyperplasia with eosinophilia and nephrotic syndrome

• Published in: International journal of dermatology Vol. 44; no. 3; pp. 242 - 244
• Main Authors: Azizzadeh, Maryam, Namazi, Mohammad Reza, Dastghaib, Ladan, Sari-Aslani, Fatemeh
• Format: Journal Article
• Language: English
• Published: 01.03.2005
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/j.1365-4632.2004.02030.x

A 45-year-old woman from Afghanistan presented with a 1-year history of multiple itching and stinging lesions on both right and left auricular and periauricular areas. Skin examination revealed about eight superficial erythematous nodules, ranging from 0.2 to 1.2 cm in diameter, on both ears, as well as on the preauricular and retroauricular areas (). Examination of a lesional skin biopsy specimen revealed vascular proliferation and dense dermal infiltration by lymphocytes, eosinophils, and mast cells. The vascular component consisted of thick- and thin-walled blood vessels lined by plump endothelial cells with large nuclei and abundant eosinophilic cytoplasm. No lymphoid follicles were identified (). The patient's medical history was remarkable for the gradual development of generalized edema starting 4 months after the appearance of the skin lesions. Laboratory investigation revealed the presence of massive proteinuria (11 g/day; normal, < 150 mg/day) and hematuria (12 red blood cells/high-power field; normal, < 1-2 red blood cells/high-power field), in association with hypoproteinemia (3.7 g/dL; normal, 5.5-8 g/dL) and hypercholesterolemia (489 mg/dL; normal, 50-220 mg/dL). The blood urea nitrogen (14 mg/dL; normal, 5-23 mg/dL) and serum creatinine (0.8 mg/dL; normal, 0.6-1.6 mg/dL) levels were within normal limits. A pathologic study of a renal biopsy specimen confirmed the diagnosis of diffuse mesangial proliferative nephropathy ().