Imidazo[1,2-a]pyrimidines as functionally selective GABA sub(A) ligands

Imidazo[1,2-a]pyrimidines are GABA sub(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha sub(3) subtype over the alpha sub(1) subtype. SAR studies to optimize this functional selectivity are described.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 16; no. 5; pp. 1175 - 1179
Main Authors Blackaby, Wesley P, Atack, John R, Bromidge, Frances, Castro, Jose L, Goodacre, Simon C, Hallett, David J, Lewis, Richard T, Marshall, George R, Pike, Andrew, Smith, Alison J, Street, Leslie J, Tattersall, David FD, Wafford, Keith A
Format Journal Article
LanguageEnglish
Published 01.01.2006
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Summary:Imidazo[1,2-a]pyrimidines are GABA sub(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha sub(3) subtype over the alpha sub(1) subtype. SAR studies to optimize this functional selectivity are described.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.11.112