Interleukin-10 Inhibits Gram-Negative-Microbe-Specific Human Receptor Activator of NF- Kappa B Ligand-Positive CD4 super(+)-Th1-Cell-Associated Alveolar Bone Loss In Vivo

To study anti-inflammatory cytokine effects on RANKL super(+)-T-cell-mediated osteoclastogenesis in vivo, we injected human interleukin-10 (hIL-10) into pathogen-infected HuPBL-NOD/SCID mice. The results show significantly decreased RANKL super(+) Th1-associated alveolar bone loss and coexpression o...

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Published inInfection and immunity Vol. 74; no. 8; pp. 4927 - 4931
Main Authors Zhang, Xiaoxia, Teng, Yen-Tung A
Format Journal Article
LanguageEnglish
Published 01.08.2006
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Summary:To study anti-inflammatory cytokine effects on RANKL super(+)-T-cell-mediated osteoclastogenesis in vivo, we injected human interleukin-10 (hIL-10) into pathogen-infected HuPBL-NOD/SCID mice. The results show significantly decreased RANKL super(+) Th1-associated alveolar bone loss and coexpression of human gamma interferon (hIFN- gamma ) and human macrophage colony-stimulating factor, but not hIL-4, in RANKL super(+) Th cells compatible with those from successfully treated aggressive periodontitis subjects. Thus, there are critical cytokine interactions linking hIFN- gamma super(+) Th1 cells to RANKL-RANK/OPG signaling for periodontal osteoclastogenesis in vivo.
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ISSN:0019-9567
1098-5522