2-Aryloxymethylmorpholine histamine H sub(3) antagonists

The synthesis and biological activity of a new series of 2- aryloxymethylmorpholine histamine H sub(3) antagonists is described. The new compounds are high affinity histamine H sub(3) ligands that penetrate the CNS and occupy the histamine H sub(3) receptor in rat brain.

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 18; no. 21; pp. 5796 - 5799
Main Authors Letavic, Michael A, Keith, John M, Ly, Kiev S, Bonaventure, Pascal, Feinstein, Mark A, Lord, Brian, Miller, Kirsten L, Motley, STimothy, Nepomuceno, Diane, Sutton, Steven W, Carruthers, Nicholas I
Format Journal Article
LanguageEnglish
Published 01.11.2008
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Summary:The synthesis and biological activity of a new series of 2- aryloxymethylmorpholine histamine H sub(3) antagonists is described. The new compounds are high affinity histamine H sub(3) ligands that penetrate the CNS and occupy the histamine H sub(3) receptor in rat brain.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmcl.2008.09.077