Synthesis and biological activity of piperazine and diazepane amides that are histamine H sub(3) antagonists and serotonin reuptake inhibitors

The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H sub(3) ligands and serotonin reuptake inhibitors.

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 18; no. 1; pp. 39 - 43
Main Authors Ly, Kiev S, Letavic, Michael A, Keith, John M, Miller, Jennifer M, Stocking, Emily M, Barbier, Ann J, Bonaventure, Pascal, Lord, Brian, Jiang, Xiaohui, Boggs, Jamin D, Dvorak, Lisa, Miller, Kirsten L, Nepomuceno, Diane, Wilson, Sandy J, Carruthers, Nicholas I
Format Journal Article
LanguageEnglish
Published 01.01.2008
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Summary:The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H sub(3) ligands and serotonin reuptake inhibitors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Feature-2
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmcl.2007.11.016