A case of severe carbamazepine overdose treated successfully with combined hemoperfusion and hemodialysis technique

Carbamazepine intoxication manifests as altered mental status ranging from drowsiness to a coma and/or cardiac abnormalities such as sinus tachycardia, prolongation of the QRS interval, ventricular tachycardia, and hypotension. The patient may be agitated, but central nervous system (CNS) depression...

Full description

Saved in:
Bibliographic Details
Published inSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Vol. 28; no. 4; pp. 906 - 908
Main Authors Vallianou, Natalia, Giannopoulou, Myrto, Trigkidis, Kyriakos, Bei, Elefteria, Margellou, Evangelia, Apostolou, Theofanis
Format Report
LanguageEnglish
Published 01.07.2017
Online AccessGet full text

Cover

More Information
Summary:Carbamazepine intoxication manifests as altered mental status ranging from drowsiness to a coma and/or cardiac abnormalities such as sinus tachycardia, prolongation of the QRS interval, ventricular tachycardia, and hypotension. The patient may be agitated, but central nervous system (CNS) depression and presentation with coma is more common and could be lethal. Serious CNS toxicity often requires hemoperfusion and/or hemodialysis (HD). Herein, we present a case of a comatose patient, who was treated with a combination of hemoperfusion and HD in series. Our approach to treat the patient with a combination of hemoperfusion and HD was based on evidence from the literature supporting that the hemoperfusion and HD in series might provide the best clearance of carbamazepine.
Bibliography:ObjectType-Case Study-2
content type line 59
SourceType-Reports-1
ObjectType-Report-1
ISSN:1319-2442