Cross-resistance and associated resistance in 2478 Escherichia coli isolates from the Pan-European ECO times SENS Project surveying the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections

The antimicrobial resistance profiles, comprising 12 antibiotics, of 2478 isolates of Escherichia coli from the ECO times SENS Project involving women with acute uncomplicated urinary tract infection at 252 community health care centres in 17 countries were determined. Resistance to ampicillin alone...

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Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 52; no. 1; pp. 128 - 131
Main Authors Kahlmeter, G, Menday, P
Format Journal Article
LanguageEnglish
Published 01.07.2003
Subjects
Escherichia coli
Portugal
Spain
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Summary:The antimicrobial resistance profiles, comprising 12 antibiotics, of 2478 isolates of Escherichia coli from the ECO times SENS Project involving women with acute uncomplicated urinary tract infection at 252 community health care centres in 17 countries were determined. Resistance to ampicillin alone (6.3%) and sulfamethoxazole alone (5.4%) were the most common 'single resistances'. Multiple resistance was most common in Spain and least common in Finland. The main associated-resistance profiles involved ampicillin/sulfamethoxazole (8.7%) and ampicillin/sulfamethoxazole/trimethoprim/trimethoprim-sulfamethoxa zole (6.4%). The most common profile of multiple resistance was ampicillin/sulfamethoxazole/trimethoprim/ trimethoprim-sulfamethoxazole/nalidixic acid/ciprofloxacin. Twenty-one isolates, half of which came from Spain, were resistant to seven antibiotics or more. Three isolates, one from Spain and two from Portugal, were resistant to nine of the 12 antibiotics investigated.
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ISSN:0305-7453
DOI:10.1093/jac/dkg280