Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic beta -cells viaAMPK activation

Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate o...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 76; pp. 11222 - 11225
Main Authors Pasternak, L, Meltzer-Mats, E, Babai-Shani, G, Cohen, G, Viskind, O, Eckel, J, Cerasi, E, Sasson, S, Gruzman, A
Format Journal Article
LanguageEnglish
Published 01.08.2014
Subjects
Derivatives
Drugs
Glucose
Insulin
Kinases
Muscles
Secretions
Uptakes
Online AccessGet full text

Cover

More Information
Summary:Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E beta -cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-2
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03310h