Relationship between the Level of Circulating CD45 super(+) Platelets and Development of Restenosis after Implantation of Drug-Eluting Stents to Patients with Coronary Heart Disease

• Published in: Bulletin of experimental biology and medicine Vol. 162; no. 4; pp. 524 - 527
• Main Authors: Gabbasov, Z A, Kozlov, S G, Byazrova, S V, Mel'nikov, I S, Saburova, O S
• Format: Journal Article
• Language: English
• Published: 01.02.2017
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-017-3653-x

The study was carried out in 126 patients with stable angina pectoris, who underwent elective coronary artery stenting with drug-eluting stents and follow-up angiography within 6-12 months thereafter. Five significant risk factors of restenosis were identified by binary comparisons of different variables. The logistic regression equation that included the level of CD45-positive platelets, diabetes, small vessel stenting, number of simultaneously implanted stents in one patient, and lesion length demonstrates the highest level of prediction of in-stent restenosis (OR=22.8; p<0.001). ROC-analysis demonstrated high prognostic value of the logit model (area under ROC curve 0.87, p<0.001). The data suggest that a close relationship exists between the development of restenosis and the level of circulating CD45 super(+) platelets.