Abstract 4734: Inhibitory effects of metformin on epithelial-mesenchymal transition of CD44CD117 ovarian cancer stem cells

Background: Although metformin, a first-line drug for treating diabetes, may play an important role in inhibition of epithelial ovarian cancer cell growth and cancer stem cells (CSCs), metformin at low dose showed less effect on proliferation of ovarian cancer cells. In this study, we evaluated the...

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Published inCancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 4734
Main Authors Xiao, Gary G, Zhang, Rongrong, Zhang, Ping, Wang, Hong, Hou, Dongming, Li, Wentao, Li, Chenwei
Format Journal Article
LanguageEnglish
Published 15.07.2016
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Summary:Background: Although metformin, a first-line drug for treating diabetes, may play an important role in inhibition of epithelial ovarian cancer cell growth and cancer stem cells (CSCs), metformin at low dose showed less effect on proliferation of ovarian cancer cells. In this study, we evaluated the effect of metformin at low dose on ovarian CSCs in order to understand the molecular mechanisms underlying ovarian tumorigenesis.
Bibliography:ObjectType-Article-1
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ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2016-4734