The total synthesis of K-252c (staurosporinone) viaa sequential C-H functionalisation strategy

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) viaa sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-...

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Published inChemical science (Cambridge) Vol. 7; no. 4; pp. 2706 - 2710
Main Authors Fox, J C, Gilligan, R E, Pitts, A K, Bennett, H R, Gaunt, MJ
Format Journal Article
LanguageEnglish
Published 01.03.2016
Subjects
Accumulation
Alkaloids
Aromatic compounds
Biocompatibility
Carbonyls
Chemical compounds
Strategy
Synthesis
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Summary:A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) viaa sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structural complexity of the natural product framework.
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ISSN:2041-6520
2041-6539
DOI:10.1039/c5sc04399a