Control of organ-specific autoimmunity by immunoregulatory CD4 super(+)CD25 super(+) T cells

CD4 super(+)CD25 super(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following...

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Bibliographic Details
Published inMicrobes and infection Vol. 3; no. 11; pp. 919 - 927
Main Authors McHugh, R S, Shevach, E M, Thornton, A M
Format Journal Article
LanguageEnglish
Published 01.09.2001
Subjects
CD25 antigen
CD4 antigen
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Summary:CD4 super(+)CD25 super(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25 super(-) effectors by a T-T interaction.
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ISSN:1286-4579