Homochiral crystal generation viasequential dehydration and Viedma ripening

1,2-Bis(N-benzoyl-N-methylamino)benz ene (2) forms centrosymmetric hydrate crystals (2.xH sub(2)O) and non-centrosymmetric anhydrous crystals. Dehydration of this hydrate (30 min at 140 degree C) resulted in the formation of chiral crystals (i.e.a physical racemate of the conglomerate crystals) as v...

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Bibliographic Details
Published inCrystEngComm Vol. 18; no. 23; pp. 4277 - 4280
Main Authors Sivakumar, Reajean, Askari, Mohammad S, Woo, Simon, Madwar, Carolin, Ottenwaelder, Xavier, Bohle, DScott, Cuccia, Louis A
Format Journal Article
LanguageEnglish
Published 01.06.2016
Subjects
Crystals
Dehydration
Dichroism
Diffraction
Formations
Hydrates
Ripening
X-rays
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Summary:1,2-Bis(N-benzoyl-N-methylamino)benz ene (2) forms centrosymmetric hydrate crystals (2.xH sub(2)O) and non-centrosymmetric anhydrous crystals. Dehydration of this hydrate (30 min at 140 degree C) resulted in the formation of chiral crystals (i.e.a physical racemate of the conglomerate crystals) as verified using solid-state circular dichroism and powder X-ray diffraction. Subsequent attrition-enhanced deracemization, also known as Viedma ripening, was used to obtain homochiral crystals of 2 within 5 h.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1466-8033
DOI:10.1039/c6ce00119j