Mechanical fluid flow and surfactant-TA influence activation of macrophages

We examined the effect of mechanical fluid flow and surfactant on macrophage aggregation as the indication of macrophage activation. Mechanical fluid flow enhanced aggregation in phorbol myristate acetate (PMA)-treated human myeloid leukemic cell lines (HL-60 cells), but had no effect on differentia...

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Published inIn vitro cellular & developmental biology. Animal Vol. 37; no. 5; pp. 270 - 274
Main Authors Mita, Yoshinori, Dobashi, Kunio, Nakazawa, Tsugio, Mori, Masatomo
Format Journal Article
LanguageEnglish
Published 01.05.2001
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Summary:We examined the effect of mechanical fluid flow and surfactant on macrophage aggregation as the indication of macrophage activation. Mechanical fluid flow enhanced aggregation in phorbol myristate acetate (PMA)-treated human myeloid leukemic cell lines (HL-60 cells), but had no effect on differentiation of PMA-treated HL-60 cells. Surfactant-TA (an artificial surfactant) inhibited fluid flow-induced aggregation, but had no effect on differentiation of PMA-treated HL-60 cells. Human alveolar macrophages spontaneously formed small aggregates without stimulation. This aggregation was enhanced by fluid flow and inhibited by surfactant-TA. Taken together, these data suggest that macrophage activation is affected by fluid flow and surfactants.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1071-2690
1543-706X
DOI:10.1290/1071-2690(2001)037(0270:MFFAST)2.0.CO;2