Synthesis of monodispersed pH-sensitive Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) magnetic nanoparticles and the potential medical application of adsorption for bovine serum album

• Published in: Integrated ferroelectrics Vol. 168; no. 1; pp. 183 - 194
• Main Authors: Nie, Ling-Hui, Bai, Fang-Hui, Liu, Ming-Fei, Ning, Jing, Chen, Bao-Tian, Wu, Zhi-Yong
• Format: Journal Article
• Language: English
• Published: 02.01.2016
• Subjects: Adsorption; Annealing; Coprecipitation; Nanoparticles; Stirring; Transmission electron microscopy; X-ray diffraction
• ISSN: 1058-4587; 1607-8489
• DOI: 10.1080/10584587.2016.1159943

We synthesized Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) magnetic nanoparticles (MNPs) by co-precipitation method and performed its adsorption of bovine serum albumin V(BSA (V)). The Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) MNPs in nitrogen atmosphere annealed at 400, 500, 600, 700 and 800 degree C, respectively. X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer(VSM) were used to characterize the resulting powders of the structure and properties. XRD results show that the Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) powder is a typical single-phase cubic spinel structure, and has no impurity phases. TEM results show that the Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) crystalline size is approximately 30-50 nm, which is similar with the XRD estimate results. The magnetic measurements show that Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) samples, super paramagnetic material, have high saturation magnetization and small coercivity properties. Moreover, We adopted ultraviolet spectrophotometer to analysis adsorption of BSA(V) on the Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) MNPs at room temperature, which show that annealed temperatures, pH, and stirring time can affect BSA(V) adsorption on the Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) MNPs. Most importantly, when ultrasonic stirring 2 hours in the liquor BSA(V) at pH = 7.0, the Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) samples annealed at 600 degree C has a highest value of 39.81mgg super(-1). From above these results, Ni sub(0.5)Zn sub(0.5)Fe sub(2)O sub(4) MNPs reveals a great adsorbing ability for BSA(V) that probable are a potential BSA-carrier candidate.