Differences in the Candida albicans antigenic expression after heat shock and infection

Heat-shock and infection induce changes in protein expression in C. albicans. To investigate if these alterations induce changes in antigenicity, we have compared the reactivity mediated by IgA antibodies of protein extracts from a strain of C. albicans and the same strain recovered from an infected...

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Published inRevista iberoamericana de micología Vol. 18; no. 1; pp. 6 - 11
Main Authors Calcedo, R, Larino, E, Calvo, E, Rementeria, A, Sevilla, MJ, Ponton, J, Hernando, F L
Format Journal Article
LanguageEnglish
Published 01.01.1901
Subjects
Candida albicans
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Summary:Heat-shock and infection induce changes in protein expression in C. albicans. To investigate if these alterations induce changes in antigenicity, we have compared the reactivity mediated by IgA antibodies of protein extracts from a strain of C. albicans and the same strain recovered from an infected animal, both at 24 degree C and 37 degree C. The antigenic variability was detected mainly in antigens recognized by salivary IgA. Antigens of 223, 205, 180 and 140 kDa were over-expressed in both strains at 37 degree C, indicating that variations due to heat shock were present before and after infection. The antigens were characterized as manno-proteins located at the outer side of the cell wall. An antigen of 61 kDa was also detected in which the expression decreased significantly after infection This was independent of heat shock.
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ISSN:1130-1406