IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals: Virology

The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects....

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Published inClinical microbiology and infection Vol. 21; no. 3; pp. 289.e1 - 289.e4
Main Authors Machmach, K, Abad-Molina, C, Romero-Sanchez, M C, Dominguez-Molina, B, Moyano, M, Rodriguez, M M, Rafii-El-Idrissi Benhnia, M, Jimenez-Mejias, ME, Vidal, F, Munoz-Fernandez, MA, Genebat, M, Viciana, P, Gonzalez-Escribano, M F, Leal, M, Ruiz-Mateos, E
Format Journal Article
LanguageEnglish
Published 01.03.2015
Subjects
Hepatitis C virus
Human immunodeficiency virus
Lentivirus
Retroviridae
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Summary:The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1198-743X
DOI:10.1016/j.cmi.2014.10.012