PS-053Variability In Adipokines Profile Of Newborns And Their Mothers After Dha Supplementation In Pregnancy

• Published in: Archives of disease in childhood Vol. 99; no. Suppl 2; p. A131
• Main Authors: Martin Alvarez, E, Pena-Caballero, M, Hurtado-Suazo, JA, Kajarabille, N, Lara-Villoslada, F, Ochoa, J J
• Format: Journal Article
• Language: English
• Published: 01.10.2014
• ISSN: 0003-9888
• DOI: 10.1136/archdischild-2014-307384.351

Background/aimsMost studies of DHA supplementation during pregnancy and infant development are focused on visual and neural development. However, scarce information is available about the influence of DHA supplementation on adipokines expression, which are related to adipose tissue metabolism and obesity.AimEvaluate the effect of DHA supplemented dairy drink consumption during pregnancy and breastfeeding on the expression of several adipokines in mothers (pregnancy, delivery and breastfeeding) and their newborns (birth and 2.5 months of age).Methods60 women were randomly assigned to two intervention groups: A) Control Group (n = 30); B) Supplemented Group (n = 30): The women took 2 glasses/day of the supplemented drink (400 mg DHA/day). Dietary intervention began in week 28th of pregnancy and concluded when breastfeeding stopped. Samples of blood were obtained from: the mothers, the umbilical vein and artery; the newborn at 2.5 months postpartum. Adiponectin, resistin, leptin and active PAI-1 plasma levels were determined using a panel from Luminex xMAP technology.ResultsAdiponectin was higher in the supplemented group in umbilical cord artery, whereas active-PAI showed a lower value in this group, although we observed an increase in mother's blood during delivery. Resistin did not show any difference. Leptin was higher in the supplemented group in umbilical cord.ConclusionThe most noteworthy result is the effect of DHA supplementation in umbilical cord artery adipokine levels, increasing the adiponectin and decreasing the active PAI-1. In addition, active PAI-1 increases in mothers during delivery. It is also interesting the increase in the supplemented group of leptin.