O-062Early Brain Activity And Cortical Development In Preterm Infants

• Published in: Archives of disease in childhood Vol. 99; no. Suppl 2; pp. A45 - A46
• Main Authors: Tataranno, M L, Moeskops, P, de Vries, LS, Kersbergen, K J, Groenendaal, F, van Rooij, LGM, Toet, M C, Buonocore, G, Isgum, I, Benders, MJNL
• Format: Journal Article
• Language: English
• Published: 01.10.2014
• ISSN: 0003-9888
• DOI: 10.1136/archdischild-2014-307384.130

Background and aimEarly brain activity is crucial for neuronal growth. It is well known that the cerebral cortex develops rapidly in the last trimester of pregnancy. We investigated whether early brain activity was related to the rate of cortical development over the 10 wks before term equivalent age in preterm infants.Methods35 infants (GA: 27.1 plus or minus 0.7; BW: 937 plus or minus 172) without morphine, were monitored with EEG/aEEG. Three periods were selected at 20-24 h, 32-36 h, 44-48 h. Minimum amplitude,% of timeResultsIncreased SATrate was positively associated with deltaGMv, inner and outer surface (resp beta :7.4, p:0.001; beta :46.6,p:0.002; beta :57.5, p:0.001). Consistent with these findings, ISI was negatively associated with changes in GMv, inner and outer surface ( beta :-3.4, p: 0.007; beta :-17.8, p: 0.034; beta :-27.7, p: 0.006). Min aEEG and% of time <5 mu V were associated with inner and outer surface at 40 wks (respectively: beta :46.2, p:0.043; beta :53.0, p:0.041; and beta :-2.9, p:0.025; beta :-3.5, p:0.019). No effect on thickness and gyrification was found.ConclusionsEarly brain activity seems to be associated with cortical development suggesting that adequate brain activity in the early neuronal networks is necessary to lead to growth and development of neonatal cerebral cortical brain, measured by structural MRI.