super(15)N-labelled pyrazines of triterpenic acids

Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC sub(50) in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seve...

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Published inJournal of radioanalytical and nuclear chemistry Vol. 308; no. 2; pp. 733 - 739
Main Authors Vlk, Martin, Micolova, Petra, Urban, Milan, Kvasnica, Miroslav, Saman, David, Sarek, Jan
Format Journal Article
LanguageEnglish
Published 01.05.2016
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Summary:Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC sub(50) in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their super(15)N labelled analogs. In this work, we present the synthesis and characterization of the target super(15)N labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-015-4479-5