Small molecule detection by lateral flow strips viaaptamer-gated silica nanoprobes

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of conc...

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Published inAnalyst (London) Vol. 141; no. 8; pp. 2595 - 2599
Main Authors Oezalp, VCengiz, Cam, Dilek, Hernandez, Frank J, Hernandez, Luiza I, Schaefer, Thomas, Oektem, Hueseyin A
Format Journal Article
LanguageEnglish
Published 01.04.2016
Subjects
Amplification
Detection
Nanoparticles
Nanostructure
Platforms
Recognition
Silicon dioxide
Strategy
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Summary:A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.
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ISSN:0003-2654
1364-5528
DOI:10.1039/c6an00273k